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Stability constants of potent cytotoxic copper(II) complexes with furan semicarbazones in ethanolic solutions a b c

Abstract : Potent cytotoxic copper(II) complexes of furannic semicarbazones were studied in ethanolic solutions at 258C. The four ligands used were synthesized in our laboratory, i.e. 2-furfural semicarbazone (FSC), 5-methyl 2-furfural semicarbazone (MFSC), 2-furfural 4-phenyl semicarbazone (FPSC) and 3-(2-furyl) prop-2-enal semicarbazone (FASC). The mathematical analysis was carried out with a recent computer program SIRKO which indicated the formation of one metal-ligand complex in each case and the logarithm of their stability constants are: log b52.02, 3.84, 4.58 and 4.52 for ligands FSC, MFSC, FASC and FPSC, respectively. A relation between stability and molecular weight of the ligands is proposed which may prove to be interesting as these complexes are being investigated for their cytotoxic activities.
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https://hal.univ-angers.fr/hal-03208745
Contributeur : Mustayeen Khan <>
Soumis le : vendredi 30 avril 2021 - 12:53:27
Dernière modification le : lundi 3 mai 2021 - 14:06:05

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2000-J Inorg Biochem-Ghassan.p...
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Ghassan Ibrahim, Gilles Bouet, Iris Hall, Mustayeen Khan. Stability constants of potent cytotoxic copper(II) complexes with furan semicarbazones in ethanolic solutions a b c. Journal of Inorganic Biochemistry, Elsevier, 2000, 81 (1-2), pp.29-34. ⟨10.1016/S0162-0134(00)00089-1⟩. ⟨hal-03208745⟩

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