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Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-κβ pathway

Abstract : Aim: To fabricate and evaluate curcumin-loaded transfersomes (Cur-TF) for the targeted delivery and enhanced therapeutic efficacy of curcumin for the treatment of rheumatoid arthritis (RA). Methods: Modified thin-film hydration method was used to prepare Cur-TF which were then embedded into carbopol-934 gel. They were further evaluated through in vitro techniques and in an in vivo arthritis model. Results: Cur-TF had optimal particle size, spherical morphology, high encapsulation efficiency and sustained drug release profiles. The Cur-TF gel had better in vitro skin penetration than plain curcumin. In vivo findings demonstrated improved clinical, histological and x-ray scores and reduced pro-inflammatory cytokines through NF-κβ inhibition. Conclusion: Cur-TF gel delivered curcumin to the arthritic dermal tissue through a topical route and demonstrated promising therapeutic efficacy by significantly alleviating complete Freud's adjuvant (CFA)-induced arthritis.
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https://hal.univ-angers.fr/hal-03213469
Contributeur : Laurent Lemaire <>
Soumis le : vendredi 30 avril 2021 - 13:55:30
Dernière modification le : samedi 1 mai 2021 - 03:34:30

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Eleesha Sana, Mahira Zeeshan, Qurat Ul Ain, Ashraf Ullah Khan, Irshad Hussain, et al.. Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-κβ pathway. Nanomedicine, Future Medicine, 2021, ⟨10.2217/nnm-2020-0316⟩. ⟨hal-03213469⟩

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