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In vitro and in vivo effects of [Ni(M5FTSC)2Cl2 Complex in cancer: Preliminary tests.

Abstract : The human colon adenocarcinoma-derived cell line CaCo-2 male Swiss mice and male Sprague-Dawley rats were used as model systems to study the effects of nickel (II), 5-methyl-2-furaldehyde thiosemicarbazone ligand and their complex. The stimulation effect of the complex was obtained with low concentrations from 3.7 x 10(-7) to 3.7 x 10(-6) M, while inhibiting effects occurred from 3.7 x 10(-5) to 3.7 x 10(-4) M. This study showed that Ni (II) is toxic for cultured cells. Our data suggest that the comple; according to the toxicity assays in mice and carcinogenesis assays in rats, could be used as an antimitotic agent.
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Contributeur : Mustayeen KHAN Connectez-vous pour contacter le contributeur
Soumis le : jeudi 6 mai 2021 - 21:53:12
Dernière modification le : lundi 10 mai 2021 - 09:22:45
Archivage à long terme le : : samedi 7 août 2021 - 18:18:46


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  • HAL Id : hal-03218018, version 1



E.M. Jouad, X. Do Thanh, Gilles Bouet, Stéphanie Bonneau, Mustayeen A. Khan.. In vitro and in vivo effects of [Ni(M5FTSC)2Cl2 Complex in cancer: Preliminary tests.. Anticancer Research, International Institute of Anticancer Research, 2002, 22 (3), pp.1713-1716. ⟨hal-03218018⟩



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