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Identification of coumarins in DCM bark, leaf and fruit extracts from Mammea neurophylla (Calophyllaceae) by LC-PDA-MSn

Abstract :

4-phenyl and 4-propylcoumarins display a wide variety of biological activities including anti-oxidant and anti-inflammatory effects, antiparasitical activities against Leishmania or Plasmodium as well as antibacterial, antiviral (HIV) and cytotoxic activities. Using LC-PDA-MSn we have developed a specific protocol allowing the simultaneous and qualitative detection of 4-phenyl and 4-propylcoumarins in DCM bark, fruit and leaf extracts obtained from Mammea neurophylla. By comparison of their retention times, MS and UV data with that of authentic samples, nine, seven and five 4-phenylcoumarins could be directly identified in bark, leaf and fruit extracts respectively. On the other hand, interlocking UV spectra and ESI-MSn data analysis allowed us to deduce plausible structures of five, eight and four other coumarins in bark, leaf and fruit respectively by comparison with their reported spectral data. During this study new Mammea A/AA 9-hydroxy-cyclo F and Mammea A/AB 9-hydroxy-cyclo F were identified. We believe that this protocol will be useful in case of dereplicative studies of Mammea and related species.

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Soumis le : jeudi 3 juin 2021 - 10:00:34
Dernière modification le : mercredi 20 octobre 2021 - 03:19:18




Séverine Derbré, Bach Tai Dang, Ingrid Freuze, David Guilet, Anne-Marie Le Ray, et al.. Identification of coumarins in DCM bark, leaf and fruit extracts from Mammea neurophylla (Calophyllaceae) by LC-PDA-MSn. International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, 2012, New-York, United States. Planta Medica, 78 (11), p. 1260, 2012, ⟨10.1055/s-0032-1321213⟩. ⟨hal-03247438⟩



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