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Anti-ages activity screening of molecules isolated from Tanzanian clusiaceous species

Abstract :

Advanced glycation end-products (AGEs) are involved in the progression of numerous pathologies such as diabetes or atherosclerosis. With the objective of finding molecules with inhibitory effects on AGEs formation, we have conducted a phytochemical investigation on three Tanzanian Clusiaceous species: Garcinia semseii, Garcinia volkensii and Allanblackia uluguruensis. Several polyphenolic compounds exhibiting phloroglucinol moieties [e.g. polyprenylated benzophenones, such as guttiferone F (1) or biflavonoïds, such as morelloflavone (2)] were identified and their anti-AGEs activities were evaluated using a recently developed automated assay.

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Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : jeudi 3 juin 2021 - 10:00:57
Dernière modification le : mercredi 20 octobre 2021 - 03:19:18




J. Magadula, Gatto Julia, Z. Mbwambo, Séverine Derbré, David Guilet, et al.. Anti-ages activity screening of molecules isolated from Tanzanian clusiaceous species. International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, 2012, New-York, États-Unis. Planta Medica, 78 (11), pp.1227 - 1228, 2012, ⟨10.1055/s-0032-1321060⟩. ⟨hal-03247448⟩



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