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Communication dans un congrès

Anti-inflammatory and immunomodulatory properties of polyphenolic compounds from Clusiaceae/Calophyllaceae: A focus on coumarins

Abstract :

Vascular endothelium plays a central role in the development of inflammatory and immune processes, which are involved in graft rejection [1]. Many Clusiaceae/Calophyllaceae species (pantropical plants) biosynthesize original polyphenolic compounds exhibiting antioxidant and anti-inflammatory properties [2 – 3]. Therefore, different Clusiaceae/Calophyllaceae polyphenols were selected in order to evaluate in vitro their anti-inflammatory and immunomodulatory potential towards Human Umbilical Vein Endothelial Cells (HUVECs). The VCAM-1, ICAM-1, E-selectin, HLA-I, HLA-II, HLA-E and MICA surface-expressions of HUVECs were evaluated by flow cytometry. It appeared that a few coumarins and one benzophenone at 10µM significantly inhibited the expression of several markers previously induced by TNF-α or IFN-γ cytokines, being more active that the immunosuppressive reference compound – zoledronic acid – at the same concentration. Among these active compounds, one phenylcoumarin isolated from the Malaysian Mesua lepidota T. Anderson (Calophyllaceae) was identified as a new one. By comparing biological effects with substitution patterns, preliminary structure-activity relationship was also established.

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Communication dans un congrès
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https://hal.univ-angers.fr/hal-03247828
Contributeur : Okina Université d'Angers <>
Soumis le : jeudi 3 juin 2021 - 11:41:22
Dernière modification le : vendredi 4 juin 2021 - 03:24:38

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Caroline Rouger, Séverine Derbré, Marc Litaudon, Khalijah Awang, Béatrice Charreau, et al.. Anti-inflammatory and immunomodulatory properties of polyphenolic compounds from Clusiaceae/Calophyllaceae: A focus on coumarins. 62nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research, 2014, Guimarães, Portugal. pp.P1L3, ⟨10.1055/s-0034-1394661⟩. ⟨hal-03247828⟩

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