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Article dans une revue

Structure and Anti-TB Activity of Trachylobanes from the Liverwort Jungermannia exsertifolia ssp. cordifolia

Abstract :

In the critical search for new antituberculosis lead compounds, bryophytes represent a largely untapped resource of chemically diverse structures. From the liverwort Jungermannia exsertifolia subsp. cordifolia, 11 new trachylobane diterpene derivatives, as well as three known compounds, were isolated. Their structures were elucidated by spectroscopic means, and full 1H NMR spin analysis of one model compound confirmed the relative configurational assignments of the congeners. Four of the isolates exhibited noticeable activity against virulent Mycobacterium tuberculosis H37Rv with minimal inhibitory concentrations of 61−24 μg/mL. This finding suggests that bryophytes in general and trachylobanes in particular deserve further attention in the search for new antimycobacterial leads.

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Article dans une revue
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https://hal.univ-angers.fr/hal-03247836
Contributeur : Okina Université d'Angers <>
Soumis le : jeudi 3 juin 2021 - 11:41:31
Dernière modification le : vendredi 4 juin 2021 - 03:10:02

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Jochen Scher, Andreas Schinkovitz, Josef Zapp, Yuehong Wang, Scott Franzblau, et al.. Structure and Anti-TB Activity of Trachylobanes from the Liverwort Jungermannia exsertifolia ssp. cordifolia. Journal of Natural Products, American Chemical Society, 2010, 73 (4), pp.656-63. ⟨10.1021/np900806j⟩. ⟨hal-03247836⟩

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