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Polyacetylenes from Radix et Rhizoma Notopterygii Incisi with an Inhibitory Effect on Nitric Oxide Production In Vitro

Abstract :

Notopterygium roots (Qiang Huo) have been used in traditional Chinese medicine for treating colds, inflammatory diseases like rheumatoid arthritis, and as an analgesic. The anti-inflammatory activity of the roots ofNotopterygium incisum has been evaluated by testing the inhibitory activity on nitric oxide production by inducible nitric oxide synthase. The apparent authenticity of the sample was checked by DNA sequence comparison. Using activity-guided isolation, different compounds were isolated and structurally characterized by means of NMR and mass spectroscopy. Eight polyacetylenes could be identified and were tested on their inhibitory activity on nitric oxide production in RAW 264.7 mouse macrophages using the Griess assay. Different 3-hydroxy allyl polyacetylenes exhibited significant activity (IC50: 8-acetoxyfalcarinol, 20.1 µM; falcarindiol, 9.2 µM; 9-epoxyfalcarindiol, 8.8 µM; and crithmumdiol, 23.6 µM).

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https://hal.univ-angers.fr/hal-03247837
Contributeur : Okina Université d'Angers <>
Soumis le : jeudi 3 juin 2021 - 11:41:33
Dernière modification le : vendredi 4 juin 2021 - 03:10:02

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Martina Blunder, Xin Liu, Olaf Kunert, Nora Winkler, Andreas Schinkovitz, et al.. Polyacetylenes from Radix et Rhizoma Notopterygii Incisi with an Inhibitory Effect on Nitric Oxide Production In Vitro. Planta Medica, Georg Thieme Verlag, 2014, 80 (05), pp.415-8. ⟨10.1055/s-0034-1368196⟩. ⟨hal-03247837⟩

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