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Article dans une revue

Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation

Abstract :

Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds.

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Article dans une revue
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https://hal.univ-angers.fr/hal-03247838
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Soumis le : jeudi 3 juin 2021 - 11:41:35
Dernière modification le : vendredi 4 juin 2021 - 03:10:02

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Andreas Schinkovitz, Amandeep Kaur, Ernst Urban, Martin Zehl, Gabriela Páchniková, et al.. Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation. Journal of Natural Products, American Chemical Society, 2014, 77 (4), pp.1069-73. ⟨10.1021/np4008574⟩. ⟨hal-03247838⟩

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