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Article dans une revue

Effects of FGF-2 release from a hydrogel polymer on bone mass and microarchitecture

Abstract :

Bone substitutes are widely used for filling and restoring bone defects. Among them, methacrylic polymers are employed in load-bearing bones to seal hip prostheses. Incorporation of growth factors into a polymer device could be a way to enhance bone growth. In the present study, we evaluated the capacity of poly(2-hydroxyethyl methacrylate) – pHEMA – copolymerized with 2-vinyl pyrrolidone – VP – to release proteins. Fibroblast growth factor-2 (FGF-2) was incorporated into cylinders of p(HEMA-co-VP). FGF-2 release was studied by ELISA in vitro and cylinders were implanted in the femoral condyle of white New Zealand rabbits. After 2 months post-surgery, FGF-2 was able to enhance bone formation by increasing bone volume; this effect was evidenced by an increase in trabecular number and bone gain was mainly in the form of woven bone. At 3 months post-surgery, no difference could be evidenced between animals receiving vehicle or FGF-2. Animals receiving vehicle exhibited bone mass higher than at 2 months and woven bone was replaced by mature bone with a lamellar matrix. The hydrogel polymer allowed the release of FGF-2, which in return enhanced bone regeneration soon after surgery but the effect vanished rapidly.

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Soumis le : mercredi 16 juin 2021 - 11:35:34
Dernière modification le : mercredi 19 janvier 2022 - 16:26:02
Archivage à long terme le : : vendredi 17 septembre 2021 - 18:27:48


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Guillaume Mabilleau, Eric Aguado, Izabella-Cristina Stancu, Corneliu Cincu, Michel-Félix Baslé, et al.. Effects of FGF-2 release from a hydrogel polymer on bone mass and microarchitecture. Biomaterials, Elsevier, 2008, 29 (11), pp.1593-1600. ⟨10.1016/j.biomaterials.2007.12.018⟩. ⟨hal-03261978⟩



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