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Use of glucagon-like peptide-1 receptor agonists and bone fractures: a meta-analysis of randomized clinical trials.

Abstract : BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) are at a higher risk of bone fractures independent of the use of antidiabetic medications. Furthermore, antidiabetic medications could directly affect bone metabolism. Recently, the use of dipeptidyl peptidase-4 inhibitors has been associated with a lower rate of bone fracture. The aim of the present meta-analysis was to assess whether patients with T2DM treated with glucagon-like peptide-1 receptor agonists (GLP-1Ra) present a lower incidence of bone fracture compared with patients using other antidiabetic drugs. METHODS: A search on Medline, Embase, and, as well as a manual search for randomized clinical trials of T2DM treated with either a GLP-1Ra or another antidiabetic drug for a duration of ≥24 weeks was conducted by two authors (GM, AM) independently. RESULTS: Although 28 eligible studies were identified, only seven trials reported the occurrence of at least a bone fracture in one arm of the trial. The total number of fractures was 19 (13 and six with GLP-1Ra and comparator, respectively). The pooled Mantel-Haenszel odds ratio for GLP-1Ra was 0.75 (95% confidence interval 0.28-2.02, P = 0.569) in trials versus other antidiabetic agents. CONCLUSIONS: Although preliminary, our study highlighted that the use of GLP-1Ra does not modify the risk of bone fracture in T2DM compared with the use of other antidiabetic medications.
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Soumis le : mercredi 16 juin 2021 - 12:20:24
Dernière modification le : mercredi 19 janvier 2022 - 16:26:02
Archivage à long terme le : : vendredi 17 septembre 2021 - 18:38:33


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Guillaume Mabilleau, Aleksandra Mieczkowska, Daniel Chappard. Use of glucagon-like peptide-1 receptor agonists and bone fractures: a meta-analysis of randomized clinical trials.. Journal of Diabetes, John Wiley & Sons Australia, Ltd ; Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 2014, 6, pp.260-6. ⟨10.1111/1753-0407.12102⟩. ⟨hal-03262091⟩



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