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Article dans une revue

Osteoblast-Like Cell Behavior on Porous Scaffolds Based on Poly(styrene) Fibers

Abstract :

Scaffolds of nonresorbable biomaterials can represent an interesting alternative for replacing large bone defects in some particular clinical cases with massive bone loss. Poly(styrene) microfibers were prepared by a dry spinning method. They were partially melted to provide 3D porous scaffolds. The quality of the material was assessed by Raman spectroscopy. Surface roughness was determined by atomic force microscopy and vertical interference microscopy. Saos-2 osteoblast-like cells were seeded on the surface of the fibers and left to proliferate. Cell morphology, evaluated by scanning electron microscopy, revealed that they can spread and elongate on the rough microfiber surface. Porous 3D scaffolds made of nonresorbable poly(styrene) fibers are cytocompatible biomaterials mimicking allogenic bone trabeculae and allowing the growth and development of osteoblast-like cells in vitro.

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Soumis le : lundi 21 juin 2021 - 12:57:17
Dernière modification le : mercredi 19 janvier 2022 - 16:26:02
Archivage à long terme le : : mercredi 22 septembre 2021 - 18:34:29


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Andrada Serafim, Romain Mallet, Florence Pascaretti-Grizon, Izabella-Cristina Stancu, Daniel Chappard. Osteoblast-Like Cell Behavior on Porous Scaffolds Based on Poly(styrene) Fibers. BioMed Research International , Hindawi Publishing Corporation, 2014, 2014 (609319), pp.1-6. ⟨10.1155/2014/609319⟩. ⟨hal-03265960⟩



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