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Article dans une revue

Vapreotide acetate for the treatment of esophageal variceal bleeding

Abstract :

Variceal bleeding is a life-threatening complication of portal hypertension. The recommended treatment includes the early administration of a vasoactive drug. Vapreotide is a somatostatin analogue with a different receptor affinity to octreotide. It decreases portal pressure and blood flow of collateral circulation in rats with cirrhosis. The pivotal study of early administration of vapreotide in patients with cirrhosis and variceal bleeding has shown a significant improvement in bleeding control and, in the subset of patients with significant bleeding, a significant reduction in mortality. In addition, a meta-analysis of four randomized studies has shown a significant improvement in bleeding control. Vapreotide administrated via the intravenous route is simple to use, with practically no contraindications and few, usually minor, side effects.

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Article dans une revue
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https://hal.univ-angers.fr/hal-03268434
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 23 juin 2021 - 10:58:13
Dernière modification le : jeudi 24 juin 2021 - 03:34:58

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Paul Calès. Vapreotide acetate for the treatment of esophageal variceal bleeding. Expert Review of Gastroenterology & Hepatology, Future Drugs, 2007-, 2008, 2 (2), pp.185 - 192. ⟨10.1586/17474124.2.2.185⟩. ⟨hal-03268434⟩

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