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Vasopressin in vasodilatory shock: is the heart in danger?

Abstract :

In patients with hyperdynamic hemodynamics, infusing arginine vasopressin (AVP) in advanced vasodilatory shock is usually accompanied by a decrease in cardiac output and in visceral organ blood flow. Depending on the infusion rate, this vasoconstriction also reduces coronary blood flow despite an increased coronary perfusion pressure. In a porcine model of transitory myocardial ischemia-induced left ventricular dysfunction, Müller and colleagues now report that the AVP-related coronary vaso-constriction may impede diastolic relaxation while systolic contraction remains unaffected. Although any AVP-induced myocardial ischemia undoubtedly is a crucial safety issue, these findings need to be discussed in the context of the model design, the dosing of AVP as well as the complex direct, afterload-independent and systemic, vasoconstriction-related effects on the heart.

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Article dans une revue
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https://hal.univ-angers.fr/hal-03268572
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 23 juin 2021 - 12:12:00
Dernière modification le : jeudi 24 juin 2021 - 03:34:58

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Balázs Hauser, Pierre Asfar, Enrico Calzia, Régent Laporte, Michael Georgieff, et al.. Vasopressin in vasodilatory shock: is the heart in danger?. Critical Care, BioMed Central, 2008, 12 (2), Non spécifié. ⟨10.1186/cc6839⟩. ⟨hal-03268572⟩

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