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Article dans une revue

An autopsy case of acute multiple sclerosis (Marburg's type) during pregnancy

Abstract :

We report a case of a 9-month pregnant woman who presented acute psychiatric and neurological symptoms with extensive involvement of the white matter on MRI and no oligoclonal bands on CSF examination. Despite high doses of intravenous steroids, plasmapheresis and immunosuppressive drugs, a fatal outcome (coma) was noted 8 months later. Neuropathological examination confirmed the diagnosis of Marburg's type of multiple sclerosis showing sharp-edged lesions of demyelination, giant astrocytes, numerous macrophages and little perivascular inflammation. We discuss the definition and limits of the Marburg entity with reference to acute disseminated encephalomyelitis, impact of pregnancy, unusual MRI features, neuropathology and treatment.

Type de document :
Article dans une revue
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https://hal.univ-angers.fr/hal-03268755
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 23 juin 2021 - 14:21:11
Dernière modification le : jeudi 24 juin 2021 - 03:34:59

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F. Gray, Jean-Yves Tanguy, Isabelle Richard-Crémieux, T. Jeanfaivre, Annick Barthelaix, et al.. An autopsy case of acute multiple sclerosis (Marburg's type) during pregnancy. Clinical Neurology and Neurosurgery, Elsevier, 2008, 110 (5), pp.514 - 517. ⟨10.1016/j.clineuro.2008.01.011⟩. ⟨hal-03268755⟩

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