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Overview of adverse events related to invasive procedures in the intensive care unit

Abstract :

BackgroundThis study was conducted to determine the frequency, predictors, and clinical impact of adverse events (AEs) related to invasive procedures in the intensive care unit (ICU). Methods This was a prospective observational study of ICUs in a university hospital. Results A total of 893 patients requiring invasive procedures were admitted over a 1-year period. Among these, 310 patients (34.7%) experienced a total of 505 AEs. The mean number of AEs per patient was 1.6 ± 1.1 (range, 1-7). Infectious AEs were significantly more frequent than mechanical AEs (60.4% vs 39.6%; P = .01). Factors independently associated with AE occurrence were isolation of multidrug-resistant bacteria at ICU admission, >5 invasive procedures, and ICU length of stay >8 days. Thirty-three AEs (6.5%) resulted in severe clinical impact, including 24 deaths. Ventilator-associated pneumonia (VAP) accounted for 62.5% of the deaths related to AEs. Conclusions One-third of critically ill patients experienced AEs related to invasive procedures. Severe AEs were associated with 11% of all ICU deaths. VAP was the most frequent AE related to death. An improved assessment of the risk–benefit balance before each invasive procedure and increased efforts to decrease VAP prevalence are needed to reduce AE-related mortality.

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https://hal.univ-angers.fr/hal-03268760
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 23 juin 2021 - 14:21:26
Dernière modification le : mardi 13 juillet 2021 - 03:16:11

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Véronique Pottier, Cédric Daubin, Nicolas Lerolle, Cathy Gaillard, Gérald Viquesnel, et al.. Overview of adverse events related to invasive procedures in the intensive care unit. American Journal of Infection Control, Elsevier, 2012, 40 (3), pp.241 - 246. ⟨10.1016/j.ajic.2011.04.005⟩. ⟨hal-03268760⟩

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