Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?

Abstract :

N-acetylcysteine is the classical antidote for acetaminophen overdose-induced hepatotoxicity, but its efficacy is limited by the need for early and only temporary treatment. Therefore, Yang and colleagues tested the hypothesis of whether ethyl pyruvate - another anti-inflammatory and antioxidant compound, which they had previously shown to protect against liver injury of various other etiologies - may allow circumventing these limitations. While ethyl pyruvate improved liver regeneration when administered early and during a limited period only, the opposite response was present both after delayed as well as prolonged treatment. The authors concluded that prolonged anti-inflammatory treatment is detrimental after acetaminophen intoxication-induced liver damage. On the one hand, this research paper confirms the need for biomarkers to monitor organ recovery after acetaminophen. On the other hand, this paper adds to the ongoing discussion on the usefulness of ethyl pyruvate as a resuscitation fluid in the critically ill.

Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : mercredi 23 juin 2021 - 15:28:25
Dernière modification le : jeudi 20 janvier 2022 - 12:18:02

Lien texte intégral




Florian Wagner, Pierre Asfar, Michael Georgieff, Peter Radermacher, Katja Wagner. Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?. Critical Care, BioMed Central, 2012, 16 (1), pp.1 - 3. ⟨10.1186/cc11153⟩. ⟨hal-03268913⟩



Consultations de la notice