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Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?

Abstract :

N-acetylcysteine is the classical antidote for acetaminophen overdose-induced hepatotoxicity, but its efficacy is limited by the need for early and only temporary treatment. Therefore, Yang and colleagues tested the hypothesis of whether ethyl pyruvate - another anti-inflammatory and antioxidant compound, which they had previously shown to protect against liver injury of various other etiologies - may allow circumventing these limitations. While ethyl pyruvate improved liver regeneration when administered early and during a limited period only, the opposite response was present both after delayed as well as prolonged treatment. The authors concluded that prolonged anti-inflammatory treatment is detrimental after acetaminophen intoxication-induced liver damage. On the one hand, this research paper confirms the need for biomarkers to monitor organ recovery after acetaminophen. On the other hand, this paper adds to the ongoing discussion on the usefulness of ethyl pyruvate as a resuscitation fluid in the critically ill.

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https://hal.univ-angers.fr/hal-03268913
Contributeur : Okina Université d'Angers <>
Soumis le : mercredi 23 juin 2021 - 15:28:25
Dernière modification le : jeudi 24 juin 2021 - 03:34:58

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Florian Wagner, Pierre Asfar, Michael Georgieff, Peter Radermacher, Katja Wagner. Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?. Critical Care, BioMed Central, 2012, 16 (1), pp.1 - 3. ⟨10.1186/cc11153⟩. ⟨hal-03268913⟩

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