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Results from the French National Esophageal Atresia register: one-year outcome

Anne Schneider 1 Sébastien Blanc Arnaud Bonnard Naziha Khen-Dunlop 2, 3 Frédéric Auber 4 Anne Breton 5 Guillaume Podevin 6 Rony Sfeir 7, 8 Virginie Fouquet 9 Catherine Jacquier Jean-Louis Lemelle 10 Frederic Lavrand 11 François Becmeur 12 Thierry Petit 13, 14 Marie-Laurence Poli-Merol 15, 16 Frederic Elbaz Thierry Merrot 17, 18 Jean-Luc Michel 19 Allal Hossein Manuel Lopez 20 Edouard Habonimana 21 Cécile Pelatan 22 Pascal Delagausie Philippe Buisson Philine de Vries 23 Jean Gaudin Hubert Lardy 24 Corinne Borderon 25 Joséphine Borgnon Olivier Jaby Dominique Weil 26 Didier Aubert 27 Stephan Geiss Jean Breaud 28 Anis Echaieb 29 Jane Languepin 30 Christophe Laplace Myriam Pouzac François Lefebvre 31 Frédéric Gottrand 8 Laurent Michaud 32 
14 TASC - Theory, Algorithms and Systems for Constraints
LINA - Laboratoire d'Informatique de Nantes Atlantique, Département informatique - EMN, Inria Rennes – Bretagne Atlantique
Abstract :

BACKGROUND: The aim of the present national prospective population-based study was to assess the early morbidity of esophageal atresia (EA).

METHODS: All 38 multidisciplinary French centers that care for patients with EA returned a specific questionnaire about the 1-year outcome for each patient. This information was centralized, checked, and entered into a database.

RESULTS: From the total population of 307 EA patients born in 2008 and 2009, data about the 1-year outcome were obtained from 301 (98%) patients, of whom 4% were lost to follow-up and 5% died. Medical complications occurred in 34% of the patients: anastomotic leaks (8%), recurrent tracheoesophageal fistula (4%), and anastomotic stenosis (22%); all of the latter group needed dilation (median, 2 dilations/patient). A new hospitalization was required for 59% of patients (2.5 hospitalizations/patient) for digestive (52%) or respiratory (48%) reasons. Twelve percent of patients required antireflux surgery at a median age of 164 days (range, 33-398 days), and 1% underwent an aortopexy for severe tracheomalacia. The weight/age Z-score was -0.8 (range, -5.5 to 3.7 months) at 12 months. Fifteen percent of patients were undernourished at 12 months of age, whereas 37% presented with respiratory symptoms and 15% had dysphagia at the last follow-up. Significant independent factors associated with medical complications were anastomotic esophageal tension (p = .0009) and presence of a gastrostomy (p = .0002); exclusive oral feeding at discharge was associated with a decreased risk of complications (p = .007).

CONCLUSIONS: Digestive and respiratory morbidities remain frequent during the first year of life and are associated with difficult anastomosis and lack of full oral feeding.

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Soumis le : jeudi 24 juin 2021 - 10:57:48
Dernière modification le : lundi 14 novembre 2022 - 01:44:05

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Anne Schneider, Sébastien Blanc, Arnaud Bonnard, Naziha Khen-Dunlop, Frédéric Auber, et al.. Results from the French National Esophageal Atresia register: one-year outcome. Orphanet Journal of Rare Diseases, 2014, 9 (1), Non spécifié. ⟨10.1186/s13023-014-0206-5⟩. ⟨hal-03269630⟩



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