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Marqueurs d'infection par virus des hépatites B, C et D et vaccination contre l'hépatite B chez des personnels de santé d'un district rural du Cameroun

Abstract :

Ninety-three health care workers (HCW) in the Tokombere sahelian district volunteered to participate in a trial to investigate viral markers of hepatitis B, C, and D and HB vaccination status.

METHODS: . Sera were tested using the Vikia HBsAg kit followed by CMIA for detection of HBsAg, anti-HBs, anti-HBc, and anti-HCV. HBsAg-positive HCW were tested for HBV-DNA, anti-HDV, and, if positive for anti-HDV, HDV-RNA.

RESULTS: Analysis of anti-HBc positivity indicated that 91% of HCW had been infected by HBV, regardless of vaccination history. Vikia HBsAg results were confirmed by chemiluminescent microparticle immunoassay (CMIA) in all HCW and were positive in 17 HCW with virus load >2000 IU/mL in 6 and HDV co-infection in 6. Anti-HCV was found in 6 HCW. Among the 55 HCW that had not been vaccinated, only 3 needed vaccination because of anti-HBc negativity. Among HCW considered for HBV treatment, one patient presenting HBV/HDV co-infection was excluded after diagnosis of hepatocarcinoma.

CONCLUSION: Systematic HB vaccination of new HCW appears unnecessary in this rural region of Africa. Anti-HBc screening is cost-effective for identifying HCW requiring vaccination. Vikia HBsAg is effective for point-of-care screening. We underline the need for universal early (preferably neonatal) HB vaccination and for availability of anti-HBV drug in limited-resource countries.

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https://hal.univ-angers.fr/hal-03269631
Contributeur : Okina Université d'Angers <>
Soumis le : jeudi 24 juin 2021 - 10:57:52
Dernière modification le : mardi 13 juillet 2021 - 03:26:52

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  • HAL Id : hal-03269631, version 1
  • OKINA : ua12663

Citation

Jacques Birguel, J.-G. Ndong, S. Akhavan, G. Moreau, Jean-Jacques Sobnangou, et al.. Marqueurs d'infection par virus des hépatites B, C et D et vaccination contre l'hépatite B chez des personnels de santé d'un district rural du Cameroun. Medecine Tropicale, Institut de Medecine Tropicale, 2011, 71 (2), pp.201-202. ⟨hal-03269631⟩

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