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Thyroxine Therapy in Euthyroid Patients Does Not Affect Body Composition or Muscular Function

Abstract :

OBJECTIVE:The main objective of the study was to evaluate the effects of small increments in thyroxine (T4) levels following levothyroxine (L-T4) administration on the body composition of women patients. The secondary objective was to assess the effect of the therapy on energy expenditure and muscular function. METHODS: The prospective, randomized study consisted of a 12-month follow-up of 37 women with thyroid nodules. The patients were divided into two groups for comparison, one treated with L-T4 (20 women) and the other untreated (17 women). L-T4 dose was individually adjusted to obtain a serum thyroid-stimulating hormone in the lower portion of the normal range. Multiple tests, including bioelectrical impedance analysis, dual-energy X-ray absorptiometry, air displacement plethysmography, measurement of waist circumference, and skinfold anthropometry, were used to investigate the muscular, fat, and water compartments; energy expenditure and muscular function were assessed by cycle ergometry. RESULTS: There were no significant differences in body composition, heart rate, energy metabolism, or muscular function between the group of women treated with L-T4 and the untreated group. CONCLUSION: The controlled increase of circulating T4 does not appear to modify the body composition or muscular function in women patients.

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Soumis le : jeudi 1 juillet 2021 - 12:21:54
Dernière modification le : mercredi 19 janvier 2022 - 16:26:02




Séverine Dubois, Pierre Abraham, Vincent Rohmer, Patrice Rodien, Maurice Audran, et al.. Thyroxine Therapy in Euthyroid Patients Does Not Affect Body Composition or Muscular Function. Thyroid, Mary Ann Liebert, 2008, 18 (1), pp.13 - 19. ⟨10.1089/thy.2007.0037⟩. ⟨hal-03275628⟩



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