Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

Abstract :

Epidemiological studies report that exposure to pesticides like chlordecone and lindane increases risk of cancer. They may act as endocrine disruptors via the activation of estrogen receptor α (ERα). Carcinogenesis involved angiogenesis and no available data regarding these organochlorines have been reported. The present study aimed at investigating the effects of lindane and chlordecone on cellular processes leading to angiogenesis through an involvement of ERα. Angiogenesis has been analyzed both in vitro, on human endothelial cells, and in vivo by quantifying neovascularization with the use of ECMgel® plug in mice. Both pesticides increased endothelial cell proliferation, migration and MMP2 activity. These toxics potentiated cell adhesion by enhancing FAK phosphorylation and stress fibers. The two organochlorines increased nitric oxide production via an enhancement of eNOS activity without modification of oxidative stress. Evidence has been provided that the two toxins increased in vivo neovascularization. Most interestingly, all the above processes were either partially or completely prevented after silencing of ERα. Altogether, these data highlight that organochlorines modulate cellular angiogenic processes through activation of ERα. This study further reinforces the harmful effects of these pesticides in carcinogenesis, particularly in the modulation of angiogenesis, a critical step in tumor promotion, through ERα.

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03275634
Contributeur : Okina Université d'Angers <>
Soumis le : jeudi 1 juillet 2021 - 12:22:29
Dernière modification le : lundi 12 juillet 2021 - 15:30:24

Fichier

clere_angiogenesis_2012.pdf
Accord explicite pour ce dépôt

Identifiants

Collections

Citation

Nicolas Clere, Emilie Lauret, Yves Malthièry, Ramaroson Andriantsitohaina, Sébastien Faure. Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis. Angiogenesis, Springer Verlag, 2012, 15 (4), pp.745 - 760. ⟨10.1007/s10456-012-9288-7⟩. ⟨hal-03275634⟩

Partager

Métriques

Consultations de la notice

8

Téléchargements de fichiers

11