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Article dans une revue

Microvesicles: Intercellular Vectors of Biological Messages

Abstract :

Cells communicate directly by cell-cell contact and indirectly via the release of mediators. But gaining a greater appreciation recently is the identification and characterization of intercellular communication through the secretion of microvesicles (MVs). MVs—small vesicles that comprise microparticles (MPs) and exosomes (1) —released from a wide variety of cells, can be considered micro-messengers. Whereas exosomes are released into the extracellular compartment by exocytosis, MPs are shed from the blebbing plasma membrane, and the composition and effects of both on target cells differ depending on the cell from which originate and the type of stimulus involved in their formation. MVs are obtained after several steps of centrifugation, whereby MPs are defined as the MVs obtained by centrifugation at < 100,000 × g, whereas exosomes are isolated by centrifugation at > 100,000 × g. Because the processes by which exosomes and MPs work are different, some researchers have claimed that such broad observations impede the defining and understanding of MV actions (2).

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Article dans une revue
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https://hal.univ-angers.fr/hal-03275868
Contributeur : Okina Université d'Angers <>
Soumis le : jeudi 1 juillet 2021 - 14:29:42
Dernière modification le : vendredi 2 juillet 2021 - 03:08:04

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Simon Tual-Chalot, Daniela Leonetti, Ramaroson Andriantsitohaina, Maria Carmen Martinez. Microvesicles: Intercellular Vectors of Biological Messages. Molecular Interventions, American Society for Pharmacology and Experimental Therapeutics, 2011, 11 (2), pp.88 - 94. ⟨10.1124/mi.11.2.5⟩. ⟨hal-03275868⟩

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