Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Microvesicles: Intercellular Vectors of Biological Messages

Abstract :

Cells communicate directly by cell-cell contact and indirectly via the release of mediators. But gaining a greater appreciation recently is the identification and characterization of intercellular communication through the secretion of microvesicles (MVs). MVs—small vesicles that comprise microparticles (MPs) and exosomes (1) —released from a wide variety of cells, can be considered micro-messengers. Whereas exosomes are released into the extracellular compartment by exocytosis, MPs are shed from the blebbing plasma membrane, and the composition and effects of both on target cells differ depending on the cell from which originate and the type of stimulus involved in their formation. MVs are obtained after several steps of centrifugation, whereby MPs are defined as the MVs obtained by centrifugation at < 100,000 × g, whereas exosomes are isolated by centrifugation at > 100,000 × g. Because the processes by which exosomes and MPs work are different, some researchers have claimed that such broad observations impede the defining and understanding of MV actions (2).

Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : jeudi 1 juillet 2021 - 14:29:42
Dernière modification le : mercredi 19 janvier 2022 - 16:22:03




Simon Tual-Chalot, Daniela Leonetti, Ramaroson Andriantsitohaina, Maria Carmen Martinez. Microvesicles: Intercellular Vectors of Biological Messages. Molecular Interventions, American Society for Pharmacology and Experimental Therapeutics, 2011, 11 (2), pp.88 - 94. ⟨10.1124/mi.11.2.5⟩. ⟨hal-03275868⟩



Consultations de la notice