Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

Abstract :

Heterogeneous in size (0.1-1 µm), microparticles are small membrane vesicles released from activated and/or apoptotic cells. Although described since 1967 by Wolf, it is only since the 1990’s that microparticles have been considered as biomarkers as well as potential mediators of biological messages between cells by acting as paracrine and endocrine vectors. Detection of microparticles has been performed in biological fluids (blood, synovial fluid, saliva for instance) and some solid tissues but also from the culture medium. Levels of circulating microparticles are enhanced in a large number of pathological states including cardiovascular and metabolic disorders associated with insulin resistance and this has been linked to deleterious effects on cells from the vascular wall, mainly, endothelial cells. This review highlights the increasing impact of microparticles in major cardiovascular pathological situations associated with metabolic derangements.

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03276607
Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : vendredi 2 juillet 2021 - 11:38:58
Dernière modification le : mercredi 19 janvier 2022 - 16:22:03

Lien texte intégral

Identifiants

Collections

Citation

Abdelali Agouni, Ramaroson Andriantsitohaina, Maria Carmen Martinez. Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components. Current Vascular Pharmacology, Bentham Science Publishers, 2014, 12 (3), pp.483-492. ⟨10.2174/1570161112666140423223148⟩. ⟨hal-03276607⟩

Partager

Métriques

Consultations de la notice

6