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Article dans une revue

Quality of life and functional outcome in early school-aged children after neonatal stroke: A prospective cohort study

Abstract :


Quality of life (QoL) is recognized internationally as an efficient tool for evaluating health interventions. To our knowledge, QoL has not been specifically assessed in children after neonatal arterial ischemic stroke (AIS).


To study the QoL of early school-aged children who suffered from neonatal AIS, and QoL correlation to functional outcome.


We conducted a multicenter prospective cohort study as part of a larger study in full-term newborns with symptomatic AIS. Participating families were sent anonymous QoL questionnaires (QUALIN). Functional outcome was measured using the Wee-FIM scale. Healthy controls in the same age range were recruited in public schools. Their primary caregivers filled in the QUALIN questionnaires anonymously. We used Student's t-test and a rank test to compare patients and controls' QoL and functional outcomes.


84 children with neonatal AIS were included. The control group was composed of 74 children, of which ten were later excluded due to chronic conditions. Mean ages and QUALIN median scores did not differ between patients and controls. Median Wee-FIM scores were lower in hemiplegic children than in non-hemiplegic ones (p < 0.001). QoL scores did not seem correlated to functional outcome.


Those results could support the presence of a “disability paradox” in young children following neonatal AIS.

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Soumis le : mardi 13 juillet 2021 - 11:22:43
Dernière modification le : vendredi 19 novembre 2021 - 14:46:13




S. Darteyre, C. Renaud, Carole Vuillerot, Emilie Presles, Manoëlle Kossorotoff, et al.. Quality of life and functional outcome in early school-aged children after neonatal stroke: A prospective cohort study. European Journal of Paediatric Neurology, Elsevier, 2014, 18 (3), pp.347-353. ⟨10.1016/j.ejpn.2014.01.006⟩. ⟨hal-03285267⟩



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