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NMR diffusometry: A new perspective for nanomedicine exploration

Abstract : Nuclear Magnetic Resonance (NMR) based diffusion methods open new perspectives for nanomedicine characterization and their bioenvironment interaction understanding. This review summarizes the theoretical background of diffusion phenomena. Self-diffusion and mutual diffusion coefficient notions are featured. Principles, advantages, drawbacks, and key challenges of NMR diffusometry spectroscopic and imaging methods are presented. This review article also gives an overview of representative applicative works to the nanomedicine field that can contribute to elucidate important issues. Examples of in vitro characterizations such as identification of formulated species, process monitoring, drug release follow-up, 2 / 29 nanomedicine interactions with biological barriers are presented as well as possible transpositions for studying in vivo nanomedicine fate.
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https://hal.univ-angers.fr/hal-03291966
Contributeur : Florence Franconi <>
Soumis le : mardi 20 juillet 2021 - 08:54:21
Dernière modification le : vendredi 23 juillet 2021 - 11:48:29

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Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier. NMR diffusometry: A new perspective for nanomedicine exploration. Journal of Controlled Release, Elsevier, 2021, ⟨10.1016/j.jconrel.2021.07.025⟩. ⟨hal-03291966⟩

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