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Molybdenum Occupational Study in a French Cohort of Workers

Abstract : Abstract Objectives Occupational exposure to molybdenum has been poorly documented to date. Here, we present a retrospective study evaluating urinary molybdenum concentration before and after shift over a period of 2 years in exposed workers. Methods This retrospective study was conducted across eight industrial sites in France and included all workers undergoing medical follow-up for occupational molybdenum exposure. A mean of six sequential samples (before and after shift) was performed for each worker. The urinary molybdenum concentration was determined using a validated method of inductively coupled plasma-mass spectrometry. A mixed linear model was built and linear regression was used to verify the extent to which the urinary molybdenum concentration depends on the age of the workers and the sampling period. Additionally, an analysis based on individual trajectory was also performed. Results Seventy-seven workers were included in the present study. Post-shift urinary molybdenum concentrations were significantly higher than pre-shift values [median (95th percentile) 37.9 (91.1), versus 60.6 (190.0) µg g−1 creatinine, respectively, P < 0.009]. No accumulation of molybdenum over time was observed. The urinary molybdenum concentrations were not influenced by age. Four workers presented high post-shift values as a result of not adhering to protection measures (maxima of 529.8, 359.7, 386.3, and 1459.7 µg g−1 creatinine, respectively). Conclusions To our knowledge, this is the first study of occupational molybdenum exposure in France to include an individual trajectory analysis. No accumulation of molybdenum was seen but high post-shift molybdenum urinary concentrations were observed for some workers. The study emphasizes the importance of molybdenum monitoring in exposed workers.
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https://hal.univ-angers.fr/hal-03292395
Contributeur : Nathalie Clement <>
Soumis le : mardi 20 juillet 2021 - 14:12:35
Dernière modification le : mercredi 21 juillet 2021 - 03:43:51

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Guillaume Drevin, Benedicte Lelievre, Jérémie Riou, Marie Briet. Molybdenum Occupational Study in a French Cohort of Workers. Annals of Work Exposures and Health, Oxford University Press, 2021, ⟨10.1093/annweh/wxab048⟩. ⟨hal-03292395⟩

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