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Chapitre d'ouvrage

The role of Smoothened and Hh signaling in neovascularization

Abstract :

New vessel formation plays a key role not only in physiological processes such as embryonic development and wound repair but also during several pathological situations. In this respect, favoring
neovascularization represents a promising therapeutic approach that would allow inducing tissue repair. Among the candidate proteins able to modulate neovascularization, evidence show that the administration of recombinant hedgehog (Hh) protein, gene, or cell therapy based on Hh transfer or using extracellular vesicles as vectors enhance new vessel formation. Here, we summarized the role of Hh pathway on angiogenesis and its therapeutic potential during myocardial infarction and diabetes.

Type de document :
Chapitre d'ouvrage
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Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : lundi 30 août 2021 - 11:41:29
Dernière modification le : mercredi 19 janvier 2022 - 16:22:03




Raffaella Soleti, Ramaroson Andriantsitohaina, M. Carmen Martínez. The role of Smoothened and Hh signaling in neovascularization. The Smoothened receptor in cancer and regenerative medicine, M Ruat, 2014, ⟨10.1007/7355_2014_70⟩. ⟨hal-03328670⟩



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