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Caveolin-1 deficiency alters plasma lipid and lipoprotein profiles in mice.

Abstract :

Caveolae are specialized membrane microdomains formed as the result of local accumulation of cholesterol, glycosphingolipids, and the structural protein caveolin-1 (Cav-1). To further elucidate the role of Cav-1 in lipid homeostasis in-vivo, we analyzed fasting and post-prandial plasma from Cav-1 deficient mice on low or on high fat diet. In total plasma analysis, an increase in ceramide and hexosylceramide was observed. In cholesteryl ester (CE), we found an increased saturated+monounsaturated/polyunsaturated fatty acid ratio in fasting plasma of low fat fed Cav-1(-/-) mice with increased proportions of CE16:1, CE18:1, CE20:3, and decreased proportions of CE18:2 and CE22:6. Under high fat diet HDL-CE, free cholesterol and pre-beta-HDL were increased accompanied by a shift from slow to fast migrating alpha-HDL and expansion of apoE containing HDL. Our results demonstrate a significant role of Cav-1 in HDL-cholesterol metabolism and may reflect a variety of Cav-1 functions including modulation of ACAT activity and SR-BI function.

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https://hal.univ-angers.fr/hal-03328704
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 30 août 2021 - 11:48:49
Dernière modification le : mardi 31 août 2021 - 03:06:38

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Susanne Heimerl, Gerhard Liebisch, Soazig Le Lay, Alfred Böttcher, Philipp Wiesner, et al.. Caveolin-1 deficiency alters plasma lipid and lipoprotein profiles in mice.. Biochemical and biophysical research communications, 2008, 367 (4), pp.826-33. ⟨10.1016/j.bbrc.2008.01.010⟩. ⟨hal-03328704⟩

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