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Article dans une revue

Unresectable colorectal cancer liver metastases treated by intraoperative radiofrequency ablation with or without resection

Abstract :

Background

Despite neoadjuvant chemotherapy, few patients with colorectal cancer liver metastases (CRLM) are eligible for liver resection. The aim of the present study was to investigate the efficacy of introperative radiofrequency ablation (IRFA) in the treatment of unresectable CRLM.

Methods

Patients with unresectable metastases confined to the liver were eligible for this prospective, multicentre phase II study conducted between 2003 and 2008. They received IRFA treatment either with or without parenchymal resection, and underwent clinical and pathological examinations. The primary endpoint was complete hepatic response at 3 months. Overall, event-free and local progression-free survival, morbidity and quality of life were also examined.

Results

Fifty-two patients were included, all of whom received neoadjuvnt chemotherapy. They had a median of 5 (range 1–13) metastases, mostly bilateral or recurrent. A complete hepatic response was observed in 39 patients (75 (95 per cent confidence interval (c.i.) 61 to 86) per cent). Of ten patients with hepatic recurrence at 3 months, two relapses were at the site of ablation. Median follow-up was 2·9 years (95 per cent c.i. 2·5 to 3·6) years. The 1-year local progression-free survival rate was 46 (95 per cent c.i. 32 to 59) per cent, the 3-year event-free survival rate was 10 (95 per cent c.i. 21 to 64) per cent. Twenty patients had postoperative complications, including one death. Quality of life increased over time for patients without disease progression.

Conclusion

IRFA, either with or without resection, is a promising treatment option for patients with unresectable CRLM. Registration number : NTC00210106 (http://www.clinicaltrials.gov).

Type de document :
Article dans une revue
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https://hal.univ-angers.fr/hal-03329045
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 30 août 2021 - 15:40:35
Dernière modification le : mardi 31 août 2021 - 03:23:57

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S Evrard, M Rivoire, Jean-Pierre Arnaud, Emilie Lermite, C Bellera, et al.. Unresectable colorectal cancer liver metastases treated by intraoperative radiofrequency ablation with or without resection. British journal of surgery, 2012, 99 (4), pp.558-565. ⟨10.1002/bjs.8724⟩. ⟨hal-03329045⟩

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