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Article dans une revue

Should pancreaticoduodenectomy be performed in the elderly?

Abstract :

BACKGROUND/AIMS: Pancreaticoduodenectomy (PD) is indicated in benign or malignant pancreatic head diseases. It is a difficult operation with high morbidity especially in elderly patients. The aim of our study was to determine whether pancreaticoduodenectomy is associated with higher morbidity and mortality in patients ≥ 70 years old.

METHODOLOGY: During 17 years, 173 patients were operated by Whipple intervention, whatever the disease. From a prospective database, patients were divided in 2 groups (Group A ≥ 70 years old, Group B <70).

RESULTS: Postoperative mortality was not significantly higher in elderly (12% vs. 4.1%; p=0.06). However, re-intervention and morbidity were more important in univariate analysis (p=0.03 and p=0.002 respectively). In multivariate analysis, age ≥ 70 years old was not an independent prognostic factor of mortality (p=0.27) and re-intervention (p=0.07). Whereas age (p=0.04) and preoperative morbidity (p=0.02) were independent prognostic factors of morbidity.

CONCLUSIONS: PD requires careful patient selection. However, age should not be a limiting factor.

Type de document :
Article dans une revue
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Contributeur : Okina Université d'Angers <>
Soumis le : lundi 30 août 2021 - 15:40:42
Dernière modification le : mardi 31 août 2021 - 03:23:57


  • HAL Id : hal-03329050, version 1
  • OKINA : ua12828



Dorothée Brachet, Emilie Lermite, Karina Vychnevskaia, Stéphanie Mucci, Antoine Hamy, et al.. Should pancreaticoduodenectomy be performed in the elderly?. Hepato-Gastroenterology, Georg Thieme Verlag, 2012, 59 (113), pp.266-271. ⟨hal-03329050⟩



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