Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database

Abstract :

PURPOSE: There is a need to identify a subgroup of high-risk patients with node-negative colorectal cancer who have a poor long-term prognosis and may benefit from adjuvant therapies. The aim of this study was to evaluate the prognostic impact of clinical and pathological parameters in a retrospective study from a prospective, continuous database of homogenously treated patients.

METHODS: This study included 362 patients operated in a single institution for Dukes A and B (node-negative) colorectal cancer. The median follow-up was 140 months. The prognostic value of 13 clinical and pathological parameters was investigated.

RESULTS: Multivariate analysis identified six independent prognostic factors: age at time of diagnosis (hazard ratio (HR) = 1.076), number of lymph nodes removed (HR = 0.948), perineural invasion (HR = 2.173), venous invasion (HR = 1.959), lymphatic vessel invasion (HR = 2.126), and T4 stage (HR = 5.876).

CONCLUSION: These parameters could be useful in identifying patients with high-risk node-negative colorectal cancer who should be presented to adjuvant therapy.

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03329057
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 30 août 2021 - 15:40:53
Dernière modification le : mardi 31 août 2021 - 03:23:57

Lien texte intégral

Identifiants

Collections

Citation

Grégoire Desolneux, Pascal Burtin, Emilie Lermite, Roberto Bergamaschi, Antoine Hamy, et al.. Prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database. International journal of colorectal disease, 2010, 25 (7), pp.829-834. ⟨10.1007/s00384-010-0934-5⟩. ⟨hal-03329057⟩

Partager

Métriques

Consultations de la notice

20