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Esophageal atresia: data from a national cohort

Abstract :

PURPOSE: A prospective national register was established in 2008 to record all new cases of live-birth newborns with esophageal atresia (EA). This epidemiological survey was recommended as part of a national rare diseases plan.

METHODS: All 38 national centers treating EA participated by completing for each patient at first discharge a questionnaire validated by a national committee of experts. Data were centralized by the national reference center for esophageal anomalies. Quantitative and qualitative analyses were performed, with P-values of less than 0.05 considered statistically significant. Results of the 2008-2009 data collection are presented in this report.

RESULTS: Three hundred seven new living cases of EA were recorded between January 1, 2008, and December 31, 2009. The male/female sex ratio was 1.3, and the live-birth prevalence of EA was 1.8 per 10,000 births. Major characteristics were comparable to those reported in the literature. Survival was 95%, and no correlation with caseload was noted.

CONCLUSIONS: Epidemiologic surveys of congenital anomalies such as EA, which is a rare disease, provide valuable data for public health authorities and fulfill one important mission of reference centers. When compared with previous epidemiological data, this national population-based registry suggests that the incidence of EA remains stable.

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https://hal.univ-angers.fr/hal-03329106
Contributeur : Okina Université d'Angers <>
Soumis le : lundi 30 août 2021 - 15:56:39
Dernière modification le : vendredi 3 septembre 2021 - 03:32:35

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Rony Sfeir, Arnaud Bonnard, Naziha Khen-Dunlop, Frédéric Auber, Thomas Gelas, et al.. Esophageal atresia: data from a national cohort. Journal of Pediatric Surgery, 2013, 48, pp.1664-9. ⟨10.1016/j.jpedsurg.2013.03.075⟩. ⟨hal-03329106⟩

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