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First report of blaNDM-1-producing Acinetobacter baumannii isolated in Lebanon from civilians wounded during the Syrian war

Abstract :

Objectives

The emergence of carbapenem-resistant Acinetobacter baumannii has been observed worldwide. We describe the first detection of A. baumannii carrying the blaNDM-1 gene in Lebanon, isolated from Syrian patients wounded during the civil war.

Methods

Four carbapenem-resistant A. baumannii strains isolated in 2012 in the Tripoli Government Hospital, Lebanon, from civilians wounded during the Syrian war, were analysed. Susceptibility was determined by disk diffusion testing, and resistance to carbapenems was confirmed by Etest. The presence of blaOXA-23-like, blaOXA-24-like, blaOXA-58-like, blaOXA-143-like, and blaNDM was investigated by PCR. Clonal relationships were studied by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and blaOXA-51 sequence-based typing.

Results

All isolates harboured the blaNDM-1 gene and were negative for other tested carbapenemases. They all belonged to the sequence type 85 and formed a single cluster by PFGE. Finally, blaOXA-51-like gene sequencing revealed the presence of the blaOXA-94 variant in all four isolates.

Conclusion

These findings show that Syria constitutes a reservoir for NDM-1-producing bacteria. These results also highlight the need for effective measures to stop the threatening spread of such strains.

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Article dans une revue
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https://hal.univ-angers.fr/hal-03333817
Contributeur : Okina Université d'Angers <>
Soumis le : vendredi 3 septembre 2021 - 11:27:59
Dernière modification le : samedi 4 septembre 2021 - 03:26:12

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Rayane Rafei, Fouad Dabboussi, Monzer Hamze, Matthieu Eveillard, Carole Lemarié, et al.. First report of blaNDM-1-producing Acinetobacter baumannii isolated in Lebanon from civilians wounded during the Syrian war. International Journal of Infectious Diseases, Elsevier, 2014, 21, pp.21-23. ⟨10.1016/j.ijid.2014.01.004⟩. ⟨hal-03333817⟩

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