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Article dans une revue

Bone metastasis: Histological changes and pathophysiological mechanisms in osteolytic or osteosclerotic localizations. A review

Abstract :

SummaryThe development of a bone metastasis involves interactions between the tumor cells, the bone marrow microenvironment and the bone cells themselves. A better understanding of the pathophysiological changes occurring in bone metastasis can be obtained from histopathological examination of invaded specimens. This review focuses on the main molecular mechanisms implied in the localization and growth of malignant cells in the bone marrow. The corresponding histologic developmental stages are illustrated both in osteolytic (or mixed metastasis) or in the osteosclerotic forms by histological analysis, immunohistochemistry and microcomputed tomographic analysis of bone samples. In both cases, the malignant cells find a “fertile soil” in the bone marrow microenvironment. They use the growth factors released by bone cells for the coupling between osteoclasts/osteoblasts to promote their own development. In turn, they elaborate a variety of cytokines that can promote osteoclastogenesis (PTHrP, IL-1, IL-6…) or on the contrary, other growth factors that can boost the osteoblastic activity (ET1, IGFs). A “vicious circle” occurs between the malignant cells and the bone cells leading to the radiological expression of the metastasis.

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https://hal.univ-angers.fr/hal-03349503
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Soumis le : lundi 20 septembre 2021 - 15:28:44
Dernière modification le : mercredi 19 janvier 2022 - 16:26:02

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Daniel Chappard, Béatrice Bouvard, Michel-Félix Baslé, Erick Legrand, Maurice Audran. Bone metastasis: Histological changes and pathophysiological mechanisms in osteolytic or osteosclerotic localizations. A review. Morphologie, Elsevier Masson, 2011, 95 (309), pp.65 - 75. ⟨10.1016/j.morpho.2011.02.004⟩. ⟨hal-03349503⟩

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