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Article dans une revue

Glucocorticoid-Induced Osteoporosis: A Review

Abstract :

Glucocorticoid (GC)-induced osteoporosis is the main cause of secondary osteoporosis. Fractures, which are often asymptomatic, can occur in as many as 50% of patients receiving chronic GC therapy. GCs have direct and indirect effects on bone cells (osteoblasts, osteocytes, and osteoclasts) with a suppression of bone formation and an increased bone resorption. The management of patients exposed to GCs should include the use of the minimal effective dose of GC, general health measures, and adequate intakes of calcium and vitamin D. Bisphosphonates are nowadays largely used in GC-induced osteoporosis and teriparatide has proved its efficiency as well.

Type de document :
Article dans une revue
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Soumis le : mardi 21 septembre 2021 - 10:07:00
Dernière modification le : mercredi 19 janvier 2022 - 16:26:02




Béatrice Bouvard, Erick Legrand, Maurice Audran, Daniel Chappard. Glucocorticoid-Induced Osteoporosis: A Review. Clinical Reviews in Bone and Mineral Metabolism, Humana Press, 2010, 8 (1), pp.15-26. ⟨10.1007/s12018-009-9051-9⟩. ⟨hal-03350060⟩



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