Mandibular Segmental Defect Regenerated With Macroporous Biphasic Calcium Phosphate, Collagen Membrane, and Bone Marrow Graft in Dogs - Université d'Angers Accéder directement au contenu
Article Dans Une Revue Archives of Otolaryngology Head and Neck Surgery Année : 2010

Mandibular Segmental Defect Regenerated With Macroporous Biphasic Calcium Phosphate, Collagen Membrane, and Bone Marrow Graft in Dogs

Franck Jegoux
  • Fonction : Auteur
Ronan Cognet
  • Fonction : Auteur
Olivier Malard
  • Fonction : Auteur
Françoise Moreau
  • Fonction : Auteur
Guy Daculsi
  • Fonction : Auteur

Résumé

OBJECTIVE:

To reconstruct segmental mandibulectomy using calcium phosphate ceramics and collagen membrane with a delayed bone marrow grafting in experimental animals.

DESIGN:

Defects of segmental mandibulectomy were filled with calcium phosphate granules and wrapped with a collagen membrane in 4 dogs and left empty as a control in 2 dogs. Two months later, a bone marrow graft was injected into the center of the implants. Animals were humanely killed after a 16-week delay.

SUBJECTS:

Six adult beagles were included in this study.

INTERVENTION:

Segmental mandibulectomy.

MAIN OUTCOME MEASURE:

Bone ingrowth and material resorption in the reconstructed segment.

RESULTS:

Successful osseous colonization bridged the whole length of the defects. The good new bone formation at the center and the periosteum-like formation at the periphery suggest the osteoinductive role of the bone marrow graft and the healing scaffold role of the membrane.

CONCLUSIONS:

This model succeeded in regenerating a large segmental defect in the mandible. An investigation with a postimplantation radiation delivery schedule is required with the use of this model, which should be considered as a preclinical study for a bone tissue engineering approach in patients with cancer-related bone defects.

Dates et versions

hal-03350067 , version 1 (21-09-2021)

Identifiants

Citer

Franck Jegoux, Eric Goyenvalle, Ronan Cognet, Olivier Malard, Françoise Moreau, et al.. Mandibular Segmental Defect Regenerated With Macroporous Biphasic Calcium Phosphate, Collagen Membrane, and Bone Marrow Graft in Dogs. Archives of Otolaryngology Head and Neck Surgery, 2010, 136 (10), pp.971-978. ⟨10.1001/archoto.2010.173⟩. ⟨hal-03350067⟩

Collections

UNIV-ANGERS
3 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More