Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Mandibular Segmental Defect Regenerated With Macroporous Biphasic Calcium Phosphate, Collagen Membrane, and Bone Marrow Graft in Dogs

Abstract :

OBJECTIVE:

To reconstruct segmental mandibulectomy using calcium phosphate ceramics and collagen membrane with a delayed bone marrow grafting in experimental animals.

DESIGN:

Defects of segmental mandibulectomy were filled with calcium phosphate granules and wrapped with a collagen membrane in 4 dogs and left empty as a control in 2 dogs. Two months later, a bone marrow graft was injected into the center of the implants. Animals were humanely killed after a 16-week delay.

SUBJECTS:

Six adult beagles were included in this study.

INTERVENTION:

Segmental mandibulectomy.

MAIN OUTCOME MEASURE:

Bone ingrowth and material resorption in the reconstructed segment.

RESULTS:

Successful osseous colonization bridged the whole length of the defects. The good new bone formation at the center and the periosteum-like formation at the periphery suggest the osteoinductive role of the bone marrow graft and the healing scaffold role of the membrane.

CONCLUSIONS:

This model succeeded in regenerating a large segmental defect in the mandible. An investigation with a postimplantation radiation delivery schedule is required with the use of this model, which should be considered as a preclinical study for a bone tissue engineering approach in patients with cancer-related bone defects.

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03350067
Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : mardi 21 septembre 2021 - 10:07:15
Dernière modification le : mercredi 19 janvier 2022 - 16:26:02

Lien texte intégral

Identifiants

Collections

Citation

Franck Jegoux, Eric Goyenvalle, Ronan Cognet, Olivier Malard, Françoise Moreau, et al.. Mandibular Segmental Defect Regenerated With Macroporous Biphasic Calcium Phosphate, Collagen Membrane, and Bone Marrow Graft in Dogs. Archives of Otolaryngology Head and Neck Surgery, American Medical Association, 2010, 136 (10), pp.971-978. ⟨10.1001/archoto.2010.173⟩. ⟨hal-03350067⟩

Partager

Métriques

Consultations de la notice

4