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Article dans une revue

Number of drug classes taken per day may be used to access comorbidity burden in older inpatients: A pilot cross-sectional study

Abstract :

Cumulative Illness Rating Scale (CIRS) remains difficult to use in older patients, especially because of a possible memory bias while declaring a chronic disease among patients with cognitive disorders. Because acute and chronic diseases are usually treated with drugs, we hypothesized that the number of drug classes taken per day could be a surrogate measure of comorbidity burden and, thus, could be positively associated with the CIRS-G score. The aim of this study was to determine whether the CIRS-G score was associated with the number of drug classes taken per day by older inpatients in a geriatric acute care unit. Based on cross-sectional design, 324 older inpatients (85.3 ± 6.4 years, 63.3% female) were prospectively included in this study. Number of drug classes daily taken was recorded using the Anatomical Therapeutic Chemical Classification (ATCC) and the CIRS-G score was also calculated. Among studied older inpatients, the mean CIRS-G score was 8.6 ± 3.6 and the mean number of drug classes daily taken was 7.0 ± 3.7. The linear regressions showed that only the number of drug classes daily taken was significantly and positively associated with the CIRS-G score (coefficient of regression β = 0.317 for unadjusted model, β = 0.304 for fully adjusted model and β = 0.317 for backward model with all P-values < 0.001). Our findings show that there is a direct association between the CIRS-G score and the number of drugs classes daily taken among the studied sample of older inpatients.

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https://hal.univ-angers.fr/hal-03355676
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Soumis le : lundi 27 septembre 2021 - 14:53:39
Dernière modification le : mercredi 27 avril 2022 - 03:43:59

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Laure de Decker, Cyrille Launay, Cédric Annweiler, Olivier Beauchet. Number of drug classes taken per day may be used to access comorbidity burden in older inpatients: A pilot cross-sectional study. European Geriatric Medicine, Elsevier, 2013, 4, pp.S83. ⟨10.1016/j.eurger.2013.07.270⟩. ⟨hal-03355676⟩

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