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Article dans une revue

Episodic memory decline in Huntington's disease, a binding deficit?

Abstract :

BACKGROUND: Huntington's disease (HD) is characterized by episodic memory deterioration.

OBJECTIVE: Our paper investigates the cognitive mechanisms that might underlie this decline. To this aim, we tested two executive hypotheses, the binding and the inhibition hypotheses.

METHODS: Fifteen HD patients (Mean Cytosine-Adenine-Guanine repeats = 44.93, SD = 2.82), and eighteen controls matched for age, gender and education were assessed with a neuropsychological battery tapping episodic memory and several executive functions, including binding and inhibition.

RESULTS: Episodic decline in patients with HD was only related to binding performance.

CONCLUSIONS: Our study shows that HD patients suffer from a perturbation of the associative or integrative mechanisms responsible for the combination of different memory features into complex episodic representations. Damage to frontal-hippocampal circuitry in HD is likely to be responsible for this impairment.

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Article dans une revue
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Soumis le : lundi 27 septembre 2021 - 14:53:49
Dernière modification le : mercredi 27 avril 2022 - 04:44:26



Mohamad El Haj, Marie Caillaud, Luciano Fasotti, Christophe Verny, Philippe Allain. Episodic memory decline in Huntington's disease, a binding deficit?. Journal of Huntington's Disease, 2013, 2 (3), pp.305-13. ⟨10.3233/JHD-130056⟩. ⟨hal-03355680⟩



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