Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Analysis of iatrogenic risk related to anticholinergic effects using two scales in acute geriatric inpatient unit

Abstract :

Anticholinergic medications are responsible for most frequent adverse drug effects. Two scales have been elaborated as tools for prescribers: the Anticholinergic Drug Scale (ADS) of Carnahan et al., and the Anticholinergic Risk Scale (ARS) of Rudolph et al. The objective of this study was to analyze the diagnostic performance of both scales for predicting signs related to an anticholinergic effect. Method: Medical records of 1379 patients aged 75 years or older hospitalized in a geriatric acute care unit between 2002 and 2005 were studied. The analyze was made retrospectively, but data were collected prospectively. Results: Risk of appearance of total anticholinergic signs (ADS : OR 1,45, CI 95% [1,03-2,03], p=0,037 and ARS : OR 1,98, CI 95% [1,19-3,28] p<0,01) and peripheral signs (ADS: OR 1,66, CI 95% [1,22-2,26], p<0,01 and ARS : OR 1,81, CI 95% [1,19-2,75], p<0,01) increased when score was >= 3 with both scales, which wasn't the case for central signs. Conclusion: Both scales permitted to detect an increased risk of appearance of total and peripheral anticholinergic signs, but not the centrals as delirium. Interest of total anticholinergic burden remains to be demonstrated, especially for delirium risk assessment.

Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-angers.fr/hal-03355739
Contributeur : Okina Univ Angers Connectez-vous pour contacter le contributeur
Soumis le : lundi 27 septembre 2021 - 15:07:05
Dernière modification le : vendredi 6 mai 2022 - 16:04:07

Identifiants

Citation

A. Gouraud-Tanguy, M. Berlioz-Thibal, J. Brisseau, V. Aoudia, Olivier Beauchet, et al.. Analysis of iatrogenic risk related to anticholinergic effects using two scales in acute geriatric inpatient unit. Gériatrie et psychologie & neuropsychiatrie du vieillissement, John Libbey Eurotext, 2012, 10 (1), pp.27-32. ⟨10.1684/pnv.2012.0337⟩. ⟨hal-03355739⟩

Partager

Métriques

Consultations de la notice

7