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Article dans une revue

CCR7 is involved in the migration of neutrophils to lymph nodes

Abstract :

Increasing evidence suggests that neutrophils may participate in the regulation of adaptive immune responses, and can reach draining lymph nodes and cross-prime naive T cells. The aim of this study was to identify the mechanism(s) involved in the migration of neutrophils to the draining lymph nodes. We demonstrate that a subpopulation of human and mouse neutrophils express CCR7. CCR7 is rapidly expressed at the membrane upon stimulation. In vitro, stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21. In vivo, injection of complete Freund adjuvant induces a rapid recruitment of neutrophils to the lymph nodes in wild-type mice but not in Ccr7−/− mice. Moreover, intradermally injected interleukin-17–and granulocyte-macrophage colony-stimulating factor–stimulated neutrophils from wild-type mice, but not from Ccr7−/− mice, migrate to the draining lymph nodes. These results identify CCR7 as a chemokine receptor involved in the migration of neutrophils to the lymph nodes.

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https://hal.univ-angers.fr/hal-03388068
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Soumis le : mercredi 20 octobre 2021 - 11:00:52
Dernière modification le : jeudi 16 décembre 2021 - 13:24:06

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Céline Beauvillain, Pierre Cunin, Andrea Doni, Mari Scotet, Sébastien Jaillon, et al.. CCR7 is involved in the migration of neutrophils to lymph nodes. Blood, American Society of Hematology, 2011, 117 (4), pp.1196 - 1204. ⟨10.1182/blood-2009-11-254490⟩. ⟨hal-03388068⟩

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