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Article dans une revue

Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection

Abstract :

Using brain lymphoma model, we demonstrate that immunotherapy combining Treg depletion (using anti-CD25 mAb PC61) followed by intracranial CpG-ODN administration induced tumor rejection in all treated mice and led to the establishment of a memory antitumor immune response in 60% of them. This protective effect was associated with a recruitment of NK cells and, to a lesser extent, of dendritic cells, B cells and T lymphocytes. NK cell depletion abolished the protective effect of the treatment, confirming a major role of NK cells in brain tumor elimination. Each treatment used alone failed to protect brain tumor bearing mice, revealing the therapeutic benefit of combining Treg depletion and local CpG-ODN injection.

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Article dans une revue
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https://hal.univ-angers.fr/hal-03389734
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Soumis le : jeudi 21 octobre 2021 - 10:22:16
Dernière modification le : mercredi 10 novembre 2021 - 15:32:04

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Ulrich Jarry, Sabrina Donnou, Marie Vincent, Pascale Jeannin, Laurent Pineau, et al.. Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection. Journal of Neuroimmunology, Elsevier, 2014, 267 (1–2), pp.35 - 42. ⟨10.1016/j.jneuroim.2013.12.005⟩. ⟨hal-03389734⟩

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