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Article dans une revue

N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination

Abstract :

Schwann cells elaborate myelin sheaths around axons by spirally wrapping and compacting their plasma membranes. Although actin remodeling plays a crucial role in this process, the effectors that modulate the Schwann cell cytoskeleton are poorly defined. Here, we show that the actin cytoskeletal regulator, neural Wiskott-Aldrich syndrome protein (N-WASp), is upregulated in myelinating Schwann cells coincident with myelin elaboration. When N-WASp is conditionally deleted in Schwann cells at the onset of myelination, the cells continue to ensheath axons but fail to extend processes circumferentially to elaborate myelin. Myelin-related gene expression is also severely reduced in the N-WASp-deficient cells and in vitro process and lamellipodia formation are disrupted. Although affected mice demonstrate obvious motor deficits these do not appear to progress, the mutant animals achieving normal body weights and living to advanced age. Our observations demonstrate that N-WASp plays an essential role in Schwann cell maturation and myelin formation.

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https://hal.univ-angers.fr/hal-03403268
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Soumis le : mardi 26 octobre 2021 - 10:03:03
Dernière modification le : mardi 3 mai 2022 - 15:14:05

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Fuzi Jin, Baoxia Dong, John Georgiou, Qiuhong Jiang, Jinyi Zhang, et al.. N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination. Development: For advances in developmental biology and stem cells, The Company of Biologists, 2011, 138 (7), pp.1329 - 1337. ⟨10.1242/dev.058677⟩. ⟨hal-03403268⟩

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