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The vimentin-tubulin binding site peptide (Vim-TBS.58-81) crosses the plasma membrane and enters the nuclei of human glioma cells

Abstract :

Cell-penetrating peptides (CPPs) can translocate through the plasma membrane and localize in different cell compartments providing a promising delivery system for peptides, proteins, nucleic acids, and other products. Here we describe features of a novel cell-penetrating peptide derived from the intermediate filament protein vimentin, called Vim-TBS.58-81. We show that it enters cells from a glioblastoma line via endocytosis where it distributes throughout the cytoplasm and nucleus. Moreover, when coupled to the pro-apoptogenic peptide P10, it localizes to the nucleus inhibiting cell proliferation. Thus, the Vim-TBS.58-81 peptide represents an effective vector for delivery of peptides and potentially a broad range of cargos to the nucleus.

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https://hal.univ-angers.fr/hal-03403309
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Soumis le : mardi 26 octobre 2021 - 10:07:31
Dernière modification le : mardi 13 septembre 2022 - 17:07:06

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Julien Balzeau, Alan Peterson, Joël Eyer. The vimentin-tubulin binding site peptide (Vim-TBS.58-81) crosses the plasma membrane and enters the nuclei of human glioma cells. International Journal of Pharmaceutics, 2012, 423 (1), pp.77 - 83. ⟨10.1016/j.ijpharm.2011.04.067⟩. ⟨hal-03403309⟩

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