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Dual effects of resveratrol on arterial damage induced by insulin resistance in aged mice

Abstract :

Aging leads to increased insulin resistance and arterial dysfunction, with oxidative stress playing an important role. This study explored the metabolic and arterial effects of a chronic treatment with resveratrol, an antioxidant polyphenol compound that has been shown to restore insulin sensitivity and decrease oxidative stress, in old mice with or without a high-protein diet renutrition care. High-protein diet tended to increase insulin resistance and atheromatous risk. Resveratrol improved insulin sensitivity in old mice fed standard diet by decreasing homeostasis model of assessment-insulin resistance and resistin levels. However, resveratrol did not improve insulin resistance status in old mice receiving the high-protein diet. In contrast, resveratrol exhibited deleterious effects by increasing inflammation state and superoxide production and diminishing aortic distensibility. In conclusion, we demonstrate that resveratrol has beneficial or deleterious effects on insulin sensitivity and arterial function, depending on nutritional status in our models.

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Article dans une revue
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https://hal.univ-angers.fr/hal-03403961
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Soumis le : mardi 26 octobre 2021 - 13:57:23
Dernière modification le : vendredi 20 mai 2022 - 11:06:35

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Stephanie Baron, Tatiana Bedarida, Charles-Henry Cottart, Françoise Vibert, Emilie Vessieres, et al.. Dual effects of resveratrol on arterial damage induced by insulin resistance in aged mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, The Gerontological Society of America, 2014, 69 (3), pp.260 - 9. ⟨10.1093/gerona/glt081⟩. ⟨hal-03403961⟩

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