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Early compaction at day 3 may be a useful additional criterion for embryo transfer

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PURPOSE: The reduction of the number of embryos transferred while maintaining a satisfactory rate of pregnancy (PR) with in vitro fertilization calls for a refined technique of embryonic selection. This prospective study investigates the significance of early embryonic compaction at day 3 as a marker of the chances of implantation. METHODS: We examined 317 transfers and their outcome involving 509 embryos including 91 compacted embryos. RESULTS: Early compaction seems linked with the ovarian response to stimulation and embryonic quality. The PR is significantly increased when the embryonic cohort contains at least one compacted embryo (44% versus 29.5%, p = 0.01), and when at least one compacted embryo is transferred (44% versus 31%, p < 0.05). The analysis of our single embryo transfers shows that the implantation rates are significantly better for compacted embryos (50% versus 30%, p < 0.05) (OR 2.98; CI 1.02-5.28). CONCLUSION: Thus, early compaction, sometimes observed at day 3, may serve as a useful additional criterion for selecting the embryos transferred.

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https://hal.univ-angers.fr/hal-03403962
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Soumis le : mardi 26 octobre 2021 - 13:57:26
Dernière modification le : lundi 29 août 2022 - 14:42:42

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Sebastien Le Cruguel, Véronique Ferré-L’hotellier, C. Moriniere, S. Lemerle, Pascal Reynier, et al.. Early compaction at day 3 may be a useful additional criterion for embryo transfer. Journal of Assisted Reproduction and Genetics, 2013, 30 (5), pp.683 - 90. ⟨10.1007/s10815-013-9983-3⟩. ⟨hal-03403962⟩

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