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Article dans une revue

Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors

Abstract :

Tyrosine kinase inhibitors (TKIs) are currently used by most oncologists. Among their side effects, thyroid dysfunctions are nowadays clearly observed. Whereas changes in thyroid function tests have been originally described with sunitinib, we now know that many TKIs can induce hypothyroidism and hyperthyroidism. In this study, the various molecules implicated in thyroid dysfunctions are analysed and the latest data on physiopathological mechanisms are approached in order to propose a strategy of thyroid monitoring of patients on TKI therapy.

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https://hal.univ-angers.fr/hal-03403981
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Soumis le : mardi 26 octobre 2021 - 14:01:51
Dernière modification le : vendredi 9 septembre 2022 - 11:28:24

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Frédéric Illouz, D. Braun, Claire Briet, U. Schweizer, Patrice Rodien. Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors. European Journal of Endocrinology, BioScientifica, 2014, 171 (3), pp.R91 - 9. ⟨10.1530/EJE-14-0198⟩. ⟨hal-03403981⟩

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