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Mitochondrial macro-haplogroup JT may play a protective role in ovarian ageing

Abstract :

This study of 200 Caucasian women shows that the distribution of the mtDNA macro-haplogroups in patients with diminished ovarian reserve (DOR) differed significantly from that of patients with normal ovarian reserve (NOR) (p=0.02). The JT macro-haplogroup was significantly under-represented in DOR patients compared with NOR patients (p=0.006) and compared with the estimated frequency of 18.8% in the general French population (p=0.0012). Our findings suggest that the risk of a prematurely depleted ovarian reserve would be three times lower for patients carrying the JT macro-haplogroup than for patients with any of the other mtDNA haplogroups (odds ratio: 0.3; 95% CI: 0.13-0.74). If these preliminary results are confirmed in larger independent studies, they should lead to the better management of infertility.

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https://hal.univ-angers.fr/hal-03404031
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Soumis le : mardi 26 octobre 2021 - 14:15:02
Dernière modification le : mercredi 27 octobre 2021 - 04:04:38

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Pascale May-Panloup, Valérie Desquiret-Dumas, C. Moriniere, Véronique Ferré-L’hotellier, S. Lemerle, et al.. Mitochondrial macro-haplogroup JT may play a protective role in ovarian ageing. Mitochondrion, 2014, 18C, pp.1 - 6. ⟨10.1016/j.mito.2014.08.002⟩. ⟨hal-03404031⟩

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