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Article dans une revue

Anti-Ku antibodies: Clinical, genetic and diagnostic insights

Abstract :

Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.

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Article dans une revue
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Soumis le : vendredi 29 octobre 2021 - 10:38:29
Dernière modification le : samedi 30 octobre 2021 - 03:57:56




Cristina Belizna, Daniel Henrion, Alain Beucher, Christian Lavigne, A. Ghaali, et al.. Anti-Ku antibodies: Clinical, genetic and diagnostic insights. Autoimmunity reviews, 2010, 9 (10), pp.691 - 4. ⟨10.1016/j.autrev.2010.05.020⟩. ⟨hal-03408451⟩



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