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Article dans une revue

Mitochondrial energetics and therapeutics

Abstract :

Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic diseases, cancer, and aging. All these clinical manifestations arise from the central role of bioenergetics in cell biology. Although genetic therapies are maturing as the rules of bioenergetic genetics are clarified, metabolic therapies have been ineffectual. This failure results from our limited appreciation of the role of bioenergetics as the interface between the environment and the cell. A systems approach, which, ironically, was first successfully applied over 80 years ago with the introduction of the ketogenic diet, is required. Analysis of the many ways that a shift from carbohydrate glycolytic metabolism to fatty acid and ketone oxidative metabolism may modulate metabolism, signal transduction pathways, and the epigenome gives us an appreciation of the ketogenic diet and the potential for bioenergetic therapeutics.

Type de document :
Article dans une revue
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Soumis le : vendredi 29 octobre 2021 - 10:45:38
Dernière modification le : samedi 30 octobre 2021 - 03:57:59

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D. Wallace, W. Fan, Vincent Procaccio. Mitochondrial energetics and therapeutics. Annual Review of Pathology Mechanisms of Disease, 2010, 5, pp.297 - 348. ⟨10.1146/annurev.pathol.4.110807.092314⟩. ⟨hal-03408489⟩



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