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Article dans une revue

Systemic and immune manifestations in myelodysplasia: a multicenter retrospective study

Abstract :

OBJECTIVE: The presence of systemic and/or immune manifestations in myelodysplasia has been currently reported. The influence of these manifestations on the natural outcome of myelodysplastic syndrome has to be considered. We present a multicenter retrospective study (2002-2009) of patients with myelodysplastic syndrome disclosing systemic and/or immune manifestations. METHODS: Forty-six patients with myelodysplasia presenting with systemic and/or immune manifestations were compared in terms of survival with 189 patients with myelodysplasia lacking these features. RESULTS: The clinical picture in these cases consisted of fever (13%), arthralgia or arthritis (13%), and cutaneous manifestations (67%). Four cases of systemic vasculitis have been reported in our series, and they have a worse prognosis. Immune anomalies were recorded in 29% of the cases, and the presence of cryoglobulins was also associated with a worse prognosis. CONCLUSION: A difference in survival between patients with myelodysplastic syndrome with systemic manifestations and patients lacking these manifestations has been observed in the presence of systemic vasculitis and/or cryoglobulins.

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https://hal.univ-angers.fr/hal-03408516
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Soumis le : vendredi 29 octobre 2021 - 10:51:38
Dernière modification le : mercredi 10 novembre 2021 - 15:32:04

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A. de Hollanda, Alain Beucher, Daniel Henrion, Alaa Ghali, Christian Lavigne, et al.. Systemic and immune manifestations in myelodysplasia: a multicenter retrospective study. Arthritis Care & Research, 2011, 63 (8), pp.1188 - 94. ⟨10.1002/acr.20504⟩. ⟨hal-03408516⟩

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